CRISPR-Cas9

Gaetan Burgio New Data & Theory on NgAgo versus CRISPR

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By Gaetan Burgio CRISPR/Cas9 genome editing has dramatically changed our way to perform biological experiments. While highly efficient and easy to use, one limitation with CRISPR/Cas9 mediated genome editing technology is the occurrence of off-target effects and the restriction of the PAM recognition sequence. Many modifications from the original system have been proposed to improve …

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Controversy over CRISPR challenger NgAgo irreproducibility reported

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Does the new gene editing method NgAgo work or not? If not, what happened? The answers to both questions seem to depend on who you ask and what you read. As much as CRISPR has been the revolutionary in the genetic modification technology arena over past methods, could CRISPR itself in the next few years …

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Hateful politics infiltrate human genome editing debate in France

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By Elliot Hosman Summary.  A campaign calling for a moratorium on using CRISPR in human embryos was launched by a prominent French organization fighting for narrow understandings of life and family. A recent campaign calling for a ban on “transgenic” human embryos was launched by one of France’s most prominent organizations fighting for “science”-backed “one-man-one-woman” …

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Will new gene editing tech NgAgo challenge CRISPR?

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2020 Update: early NgAgo reports have been mostly discredited and there is doubt on its function as a gene-editing method. What could be better than CRISPR for gene editing? A new genetic modification technology called NgAgo has some researchers really excited. How does it compare to CRISPR? I’ll admit it that as a scientist who works on …

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New chat with George Church on CRISPR’ing people, Zika, weapons, & more

George-Church

I talked last year about human genetic modification by CRISPR with George Church a year ago. Now we’ve followed up with a long chat on this topic going into much more detail and with questions on recent developments. Each question is listed numerically and then there is a back and forth on that question with George …

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Human Gene Editing takeaways from day 1 of #GeneEditSummit

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The Summit on Human Gene Editing got off to a great start yesterday. I have four posts summarizing all the talks and my impressions on the points made (here, here, here, and here). What was the overall gestalt including from talking to people informally? What were the big takeaway messages so far from Day 1? Diverse views. …

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Weekend science reading: fantastic found links including on CIRM

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David Jensen reports on the future of CIRM as a “beautiful machine”. CIRM funds brain cancer research in a big way: Funding a clinical trial for deadly cancer is a no brainer. Glioblastoma is a fatal tumor that needs new clinical approaches so this is exciting. One of the goals of my lab is to find new …

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UK Biologist Niakan Asks to Make GM Human Embryos For Research

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UK biologist Kathy Niakan has asked governmental permission to make GM human embryos using CRISPR. Earlier this year, a research team in China crossed a scientific line for the first time in history by using gene editing technology called CRISPR-Cas9 to make genetically modified (GM) human embryos. Other researchers around the world including now one …

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Trump makes case for germline human genetic modification?

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Flying out of Portland Airport yesterday, I saw these magazines side by side: Trump and genetic modification of humans. Hmmm. That’s a humorous juxtaposition and the two covers are oddly similar in design. It go me thinking… Could using germline human genetic modification be a wise thing to do in some cases? After all, humanity …

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