September 30, 2020

The Niche

Knoepfler lab stem cell blog

CRISPR controversy

4 min read

A decade ago I wrote an article in the journal Nature Biotechnology about the rise of a new gene editing technology called zinc finger nucleases (ZNF). It was one of those “drumbeat” discoveries: at the time, my sense was it would revolutionize how we deliver genes to cells and tissues, and profoundly change the way we think about gene therapy. I was partially right. Although ZNFs are now well along in clinical trials for HIV, successive advances in precision gene editing now include transcription …Read More