July 10, 2020

The Niche

Knoepfler lab stem cell blog

CRISPR mosaicism

5 min read

We can be confident that human genetic modification via CRISPR’ing of embryos soon will be safe and effective after that new exciting Mitalipov team paper, right? Wrong. The reality is far more complicated and interesting on the tech side. In a nutshell, I see the paper as a significant scientific, but not necessarily medical advance. The media coverage overall has painted too rosy and simplistic a picture of the Mitalipov paper. Setting aside tough bioethical and societal issues regarding human genetic modification for the …Read More

3 min read

A new paper was recently published on CRISPR of human embryos for genetic modification. I’ve got to read this publication more carefully, but here’s a quick initial take on this human CRISPR 2.0 study. The paper is Kang, et al. and is entitled “Introducing precise genetic modifications into human 3PN embryos by CRISPR/Cas-mediated genome editing”. This is only the second paper reporting genetic modification of human embryos. The first paper, also from China, created quite a stir last year and reported a lot of technical …Read More