November 29, 2020

The Niche

Knoepfler lab stem cell blog

Dagan Wells

5 min read

Scientist make knockout human embryos with CRISPR? Today we see a new Nature paper (Fogarty, et al.) on CRISPR “gene editing” of human embryos, this time from the UK from Kathy Niakan’s group. Niakan got UK permission about 18 months ago to CRISPR healthy human embryos so they’ve been hard at work since. Because Fredrik Lanner of Sweden (see my interview here) also has governmental permission to CRISPR healthy human embryos, I’m guessing we’ll see a paper from his lab soon too. If I …Read More

3 min read

Today a new Nature paper from Dr. Mary Herbert’s group in the UK has found a key problem with mitochondrial replacement therapy that fits with data from others. The goal of preventing mitochondrial disease using various kinds of genome transfer technologies is a noble one, but mitochondrial replacement therapy has faced a number of technological challenges including perhaps most prominently the carryover and subsequent amplification of diseased mitochondria. This mitochondrial replacement carryover issue was clearly defined in an excellent recent Cell Stem Cell paper …Read More