October 22, 2020

The Niche

Knoepfler lab stem cell blog

David Jensen

4 min read

By Jeanne Loring There has been news over the last few days about stem cell researchers pulling out from a documentary called “The Healthcare Revolution”.  First to report on June 15 was Erin Allday of the San Francisco Chronicle, followed by David Jensen’s California Stem Cell Report blog, Michael Hiltzik of the LA Times, and Beth Mole of ArsTechnica. The documentary is a multipart series that included interviews with people designated as “Episode Experts”.  I discovered last Thursday (June 13) that I was listed …Read More

4 min read

The four words “California stem cell research” go nicely together and I hope they will continue to resonate in a special way to people around the world in the coming decade. We are at a crossroads for stem cell research in California as the original form of the California Stem Cell Agency (CIRM) winds down. Will CIRM get a new infusion of billions in state funding via a ballot initiative a la Proposition 71 from more than a decade ago? Will CIRM instead find …Read More

1 min read

What new papers and news in the stem cell sphere caught your eye? Here are some recent items that seem notable to me. Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells. This paper reports cellular reprogramming to insulin-producing cells in mice. They reprogrammed α-cells with Pdx1 and MafA proteins. ‘Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease’ in Nature Neuroscience. Using IPS cells for insights. “What open chromatin features predict pluripotency?” asked and answered by the authors of this review …Read More

2 min read

The California Institute for Regenerative Medicine, more widely known as CIRM, has accomplished big things over the course of its history of about a decade and sparked a great deal of innovation, but what does the future hold for our stem cell agency? CIRM has a new, respected President and CEO Maria Millan solving one of several challenges, but at present it doesn’t have an established concrete funding stream for when the Proposition 71 funding runs out in a few years. What happens next …Read More