June 3, 2020

The Niche

Knoepfler lab stem cell blog

deterministic reprogramming

4 min read

Researchers probing how to reprogram cells into powerful stem cells (induced pluripotent stem cells or IPSCs) and what the molecular mechanisms are behind this process have become entangled in a conflict. Of course over the years scientists including stem cell scientists have had their share of disagreements and debates in the past including heated ones, but this reprogramming clash has taken it up a notch beyond past ones and has some unique elements to it. For example, this scientific clash is unfolding largely in the public domain …Read More

4 min read

What is “radically deterministic” cellular reprogramming? Jacob Hanna’s lab recently published a very high profile Nature paper on nearly 100% efficient iPS cell formation based on targeting a factor called Mbd3. This super efficiency is a major departure from past reported efficiencies. This morning here at the Till & McCulloch Stem Cell Meeting in Banff, Hanna gave an intriguing talk telling us more about his lab’s efforts in this area. He also fielded some incisive questions from the audience (including 2 from me) after …Read More