dieter egli

Weekly reads: escape to New York, CRISPR baby patents, ISSCR guidelines, pubs

the high line in manhattan

My to-read list this weekend includes a range of papers along with various news & media including a report of two US research groups aiming to get CRISPR baby patents. More on that below. At long last a trip + fun thing to do in NYC Last week I took my first trip in more …

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CRISPR often damages human embryo chromosomes

human-embryo-modification

Three new studies reported in preprints all show severe DNA damage to human embryos from CRISPR a surprisingly high percentage of the time including in some cases loss of heterozygosity (LOH). Anywhere from about a quarter to half of CRISPR’d embryos exhibited major genome damage. As readers of The Niche know, I never was a …

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Recommended regenerative medicine reads plus COVID-19 stem cell hype

Universal-Cells

Despite the COVID-19 pandemic there are still some research things we can do including data analysis as well as reading new papers and media articles on science, including regenerative medicine. If the weather’s good and you have wi-fi (or you print articles still on paper) you can even do this out in the fresh air …

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Mitalipov rebuts CRISPR pub critiques: strengthens case, but puzzles remain

Ma-et-al.-2018-Nature-FIgure-1

Remember that Shoukhrat Mitalipov lab paper on the use of CRISPR in human embryos? It’s back in the news. One of the biggest stories of 2017 centered on a Nature paper (Ma, et al., see my quick, initial review shortly after it was published here) from Mitalipov’s lab claiming both efficient repair of a disease-causing …

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Is monkey cloning a breakthrough or a bad idea?

Monkey-clones

Is monkey cloning a good idea? We’re about to find out. A new Cell paper today reports the first cloning of monkeys via somatic cell nuclear transfer (SCNT), raising many questions. The paper from a team led by Qiang Sun is entitled, “Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer.” The highlight bullet points …

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10 Stem Cell Person of the Year Award Finalists 2017

SCPOY2017-top-10-finalists

The votes are in and the community has picked its top 10 Stem Cell Person of the Year Award finalists. Both the 20 nominees and now the 10 finalists are a diverse group. The finalists include six women and four men, from five countries and four different continents. We also got votes from readers of the blog …

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20 Stem Cell Person of The Year 2017 Award Nominees

stem-cell-person-of-the-year

Nominations have closed for the 2017 Stem Cell Person of the Year Award and we have a great group of nominees. I’ve listed them below in alphabetical order, along with a bit of description of who they are, which includes in some cases the language used by the nominator(s). Where possible I’ve included a link …

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Why Mitalipov’s ‘magic’ room for human embryo CRISPR may give us pause

Shoukhrat-Mitalipov

The debate over whether the main conclusions of the Nature paper on human embryo CRISPR led by Shoukhrat Mitalipov’s lab at Oregon Health Sciences University (OHSU) are correct remains unresolved. Note that Nature just added an editorial alert just above the references section to their paper: “Updated online 02 October 2017. Editorial Note: Readers are alerted that some …

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Mulling over that Mitalipov human embryo CRISPR pub, still many questions

human-embryo-modification

What really happened at the DNA level in the experiments in that high-profile CRISPR of human embryos paper from a team led by Shoukhrat Mitalipov at OHSU? Is the team right that they successfully conducted CRISPR of human embryos to correct a mutant gene, as they reported in their Ma, et al. Nature paper? Or is the Egli, …

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Mitalipov briefly responds to Egli preprint, stands by human embryo CRISPR pub findings

Shoukhrat-Mitalipov

There has been a wave of intense discussions both in the public domain such as on Twitter and behind the scenes over the new Egli, et al. preprint that challenges the main conclusions of the Ma, et al. Nature paper from Shoukhrat Mitalipov’s lab. Ma, et al. reported CRISPR gene editing of human embryos, arguing for …

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