July 13, 2020

The Niche

Knoepfler lab stem cell blog

DIPG

4 min read

What’s new in the stem cell, cell therapy, and regenerative medicine world as well as biomedical science more generally including cancer? There’s quite a bit of news as reflected in media pieces and new pubs. Today’s post is focused on pubs that just came out. For last week’s recommended reads see here. Oct4-Sox2 Nucleosome Binding & Impact in mESCs This is one of my favorite papers of 2020 so far, coming to us from Science. Mechanisms of OCT4-SOX2 motif readout on nucleosomes. I knew from …Read More

1 min read

The Knoepfler lab has formed a team to raise research funds to try to find new treatments and hopefully cures for kids facing a type of mostly fatal brain tumors. Here’s the team page. If you can give us a hand by joining the team or making a donation that’d be wonderful. Any help would be appreciated. The way it works is that this great pediatric cancer foundation called Alex’s Lemonade Stand Foundation, from whom I recently got a 2-year grant, will match all the money …Read More

4 min read

Sometimes in science there are unexpected threads tying seemingly very different things together. Unraveling the knots in these threads can lead to new insights into important developmental processes and mechanisms of disease. My lab studies epigenomic and transcription factors including a molecule called histone variant H3.3 (more here on H3.3). H3.3 binds to the actual thread of DNA to create very different kinds of chromatin states than those made by the more traditional canonical histone H3 family members. Think of H3.3 as the unorthodox …Read More

2 min read

Glioblastoma and other related malignant glioma tumors including diffuse intrinsic pontine glioma (DIPG) are some of the most devastating of all human cancers. You can see an image of a glioma (the white area in the brain scan) from Wikipedia above. These brain tumors usually kill the people who get them within 1-2 years even with treatments and because today’s therapies for these cancers are themselves extremely harsh, patients’ quality of life is often very poor. Brain surgery, irradiation, and chemo can leave patients …Read More