November 30, 2020

The Niche

Knoepfler lab stem cell blog

Douglass M. Turnbull

3 min read

Was an intensely hyped Nature paper connected to the subsequent knighthood for one of the authors just two days after publication? It’s hard to imagine there isn’t a connection and such a link is bad news for biomedical science. Professor Doug Turnbull and fellow UK authors published a Nature paper a few days ago that reinforced a safety concern about 3-person IVF/mitochondrial replacement. The same safety issue had also been raised by an earlier paper by a different team. However, some of the authors of the new …Read More

3 min read

Today a new Nature paper from Dr. Mary Herbert’s group in the UK has found a key problem with mitochondrial replacement therapy that fits with data from others. The goal of preventing mitochondrial disease using various kinds of genome transfer technologies is a noble one, but mitochondrial replacement therapy has faced a number of technological challenges including perhaps most prominently the carryover and subsequent amplification of diseased mitochondria. This mitochondrial replacement carryover issue was clearly defined in an excellent recent Cell Stem Cell paper …Read More