September 29, 2020

The Niche

Knoepfler lab stem cell blog

embryonic stem cells

3 min read

With stem cells for vision loss, first we want to be sure a treatment won’t make things worse. Several teams around the globe are rigorously studying stem cell-based approaches to vision loss via regulatory-compliant studies including for macular degeneration with some results cautiously upbeat on safety from early phase analyses, but data from a new study on the use of human embryonic stem cell (hESC)-derived retinal pigmented epithelial cells (RPEs) for macular degeneration are concerning in some ways. The paper in the AAO Journal from a …Read More

2 min read

Over the years, the Vatican has expressed interest and even invested money in the adult stem cell field. Not surprisingly, they’ve also been critical of embryonic stem cell research. Interestingly their own stem cell meetings have at times stimulated heated debate for various reasons and one was even cancelled with at least part of the reason related to embryonic stem cell research.

2 min read

What does a stem cell word cloud tell us about the field? Word clouds are fun and informative ways to do textual data mining. I’ve done some in the past that have providing penetrating looks at science including at the whole field of science in 2014. What has the stem cell field overall been focusing on lately? I turned to a word cloud to figure it out from the thousands of articles out there. Above is a word cloud made from all the titles of 2015 …Read More

2 min read

A new human therapeutic cloning paper is out today, the third in a matter of months. This one is from the lab group of Dr. Dieter Egli published in Nature demonstrating production of nuclear transfer embryonic stem cells (NT-ESCs) from an adult human somatic donor via somatic cell nuclear transfer (SCNT). This human SCNT paper follows on the heels of a similar paper (Chung, et al.) from Bob Lanza’s group published in Cell Stem Cell and the pioneering Mitalipov human SCNT paper (Tachibani, et al.) …Read More