May 30, 2020

The Niche

Knoepfler lab stem cell blog

epidermal stem cells

4 min read

Epidermis regeneration is an important approach to helping patients with a variety of serious skin problems that can arise due to genetic conditions or injuries such as severe burns. An exciting new Nature paper reports epidermis regeneration on a strikingly large-scale. The child who is the subject of the study suffers from a sometimes fatal genetic skin disease called junctional epidermolysis bullosa (JEB). In fact, in the particular case described in the new paper, the patient would have likely died without some transformative intervention given …Read More

2 min read

Yesterday at ISSCR 2016, Fiona Watt gave a great talk about plasticity of epidermal stem cells. As with my other #ISSCR2016 posts, this one is a stream of impressions, quotes, and key points. For my other blog posts from the meeting see here. First she provided a nice overview of human skin architecture and regulation. The position of cells within this tissue directly impacts their fate and this is true of the stem cells as well. How do stem cells in the basal layer adopt …Read More