October 31, 2020

The Niche

Knoepfler lab stem cell blog

germline modification

1 min read

Nature recently published a thorough, insightful piece on the major risks that would come with the use of so-called 3-person IVF (aka mitochondrial transfer or 3-parent baby method). In the UK 3-person IVF has, as of earlier this year, the government’s blessing to proceed despite the many serious unresolved risks that Nature‘s own piece so nicely outlines. Some scientists including myself have spoken out publicly about these risks, which include potentially disastrous developmental problems for the children produced via this method. However, others including a panel …Read More

13 min read

CRISPR-Cas9 gene editing technology is red-hot right now and I’ve been doing interviews with various thought leaders on it, which today includes Steven Pinker. This technology has great power for research in the lab and there are hypothetical transformative clinical applications of CRISPR too. The latter efforts could include experimental attempts at reversal of disease-causing mutations in one-cell embryos with the hope that they then grow into full-fledged, healthy human beings. Hypothetically CRISPR could also be used for pursuing human enhancement via germline genetic …Read More