June 1, 2020

The Niche

Knoepfler lab stem cell blog

Hamideh Emrani

3 min read

The idea of using stem cells for scleroderma seems a bit more promising today. A new NIH-funded study reported in the New England Journal of Medicine (NEJM) gives some hope for the use of a combination of a specific type of myeloablation and a transplant of hematopoietic stem cells (HSC). This approach yields improved long-term outcomes for patients with a severe form of scleroderma called systemic sclerosis. While survival rates for systemic sclerosis have improved it remains a very challenging condition with a significant …Read More

6 min read

By Hamideh Emrani (@HamidehEmrani) This year, Dr. Harold Atkins was honored with the Till & McCulloch Award. He and Dr. Mark Freedman led a clinical trial that used stem cells to reset the immune system as a treatment strategy for Multiple Sclerosis (MS) and a few other neurodegenerative diseases, such as stiff person syndrome. You can read how this trial has affected patient Jennifer Molson here. This trial was a hypothesis-driven interventional clinical trial. The researchers hypothesized that through chemotherapy they could completely obliterate the …Read More