September 20, 2020

The Niche

Knoepfler lab stem cell blog

He Jiankui

6 min read

Three new studies reported in preprints all show severe DNA damage to human embryos from CRISPR a surprisingly high percentage of the time including in some cases loss of heterozygosity (LOH). Anywhere from about a quarter to half of CRISPR’d embryos exhibited major genome damage. As readers of The Niche know, I never was a fan of the idea of doing CRISPR on human embryos for reproductive use, although I have been supportive of limited, thoughtful in vitro gene-editing studies on human embryos. The …Read More

3 min read

Organoids are providing a novel avenue into the pathogenesis of COVID-19 and novel models for drug screening. A number of new preprints on respiratory organoids shed new light in this area. They were highlighted in a Nature newsy piece, Mini organs reveal how the coronavirus ravages the body. It’s a challenge to study COVID-19 infections because just infecting 2D cultures of various respiratory cells in a dish doesn’t necessarily tell you all you need to know about what goes on in the patient. While 3D organoids aren’t …Read More

7 min read

Making a CRISPR baby is a controversial idea to even propose now for many reasons, yet even after He Jiankui’s train wreck some people have seemed eager to try it including apparently a scientist whose name perhaps many readers here are not so familiar with in this context: Professor Hui Yang. ‘CRISPR baby guys’ Is it really a good time to be pushing CRISPR babies? The original “CRISPR baby guy” He Jiankui was recently sentenced to three years in prison for a variety of actions …Read More

4 min read

Scientist He Jiankui(贺建奎) has been sentenced to 3 years in prison by Chinese authorities. Two collaborators also will go to jail. A piece in Science by Dennis Normile on the sentencing of He Jiankui ID’d the other two: “His collaborators were identified as Zhang Renli, of a medical institution in Guangdong province, and Qin Jinzhou, from a Shenzhen medical institution.” Is this jail term an appropriate or even positive outcome here all things considered? Over the top? Dr. He became known colloquially as “the CRISPR baby guy” …Read More