May 31, 2020

The Niche

Knoepfler lab stem cell blog

heart stem cells

4 min read

What’s on your weekend reads list including stem cell papers? In addition to hard-core research papers, I find some bigger picture publications to be helpful too. Then there are just fun items. Every so often I do a post about things that I’m hoping to find time to read over the weekend or that I’ve recently read. Today’s post is one of those items and here are some interesting science reads related in particular to stem cells, cancer, and CRISPR. Stem cell research and …Read More

2 min read

The exciting and sometimes downright crazy giant stem cell ecosystem of legit research and unproven stem cell clinics could use a dose of good news now and then. In today post, I highlight some upbeat news and some interesting recent pubs. Enjoy! From a team led by Hina Chaudhry, MD, Director of Cardiovascular Regenerative Medicine at the Icahn School of Medicine at Mt. Sinai, a new PNAS pub, “Multipotent fetal-derived Cdx2 cells from placenta regenerate the heart.” Congrats to first author Sangeetha Vadakke-MadathilThis is a …Read More

2 min read

There’s always debate about stem cells and regenerative medicine, right? There are very strong opinions in our field. Here is a list of 10 current, provocative questions. I have my own ideas about the answers to these. Weigh in with comments with your answers. I’m going to do a follow up post with some discussion of the questions. I may do another follow up with the top 10 policy questions in our arena. Here’s today’s list in no particular order.

1 min read

Can stem cells mend a broken heart via cardiac regenerative medicine? The idea of the use of stem cells and regenerative medicine strategies for heart disease has taken us on a roller coaster ride over the years. There are many controversial questions still such as whether the adult heart has meaningful populations of endogenous stem cells. Can administration of stem cells help a damaged heart? Where do things stand today? As Deepak Srivastava, cardiac stem cell expert, told in me for a past blog post …Read More

2 min read

Imagine what stem cells might be able to do in terms of revolutionizing medicine and society in coming decades including via a human body shop. It’s an exciting time. One cool notion that’s been out there for a long time (e.g. see this Tech Review piece from 2001) is The Human Body Shop. I’d extend that to The Stem Cell Human Body Shop as I’ve discussed in my book and in this 2013 radio interview. How would this work?In the future it may literally be …Read More

2 min read

Can hearts repair themselves via stem cell-like mechanisms? Sometimes what we scientists all know to be true turns out later on to be wrong and there are clear instances of this in the stem cell field. For example for decades the dogma was that the adult mammalian brain did not have stem cells, but now everyone knows that the adult brain does have stem cells. What we perceive as factual can change over time. Yamanaka disproved the entrenched notion that differentiated cells were permanently locked into …Read More