heteroplasmy

Mitochondrial Replacement Hype Goes Nuclear Including by Wellcome Trust

BBC-hype-mito-replacement

A new paper from a UK team yesterday showed that mitochondrial replacement therapy faces a serious and difficult safety hurdle fitting with similar findings from an earlier recent study from a different team led by Dieter Egli, but the UK media and some scientists there are engaging in hype, claiming the exact opposite. They are pushing the unscientific …

Mitochondrial Replacement Hype Goes Nuclear Including by Wellcome Trust Read More »

Juan Carlos Izpisua Belmonte Cell Paper on Gene Editing for Mitochondrial Disease

Figure-6B

The Juan Carlos Izpisua Belmonte group published a Cell paper today on using gene editing to reverse mutations associated with human mitochondrial disease. The paper is Reddy, et al. and is entitled, “Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing”. The authors report success using TALEN-based gene editing or mitochondrial-direct restriction enzyme (mito-ApaLI) …

Juan Carlos Izpisua Belmonte Cell Paper on Gene Editing for Mitochondrial Disease Read More »

Response from Drs. Braude & Lovell-Badge to My Letter on Mitochondrial Transfer/3-Parent Technology

3-parent-baby

The following is a response to my Open Letter to the UK Parliament on mitochondrial transfer/3-parent technology from Drs. Peter Braude and Robin Lovell-Badge. Dear Professor Knoepfler, We read your open letter to the UK Parliament and the Science and Technology Committee with interest and concern. We are two scientists, like you, with particular interests …

Response from Drs. Braude & Lovell-Badge to My Letter on Mitochondrial Transfer/3-Parent Technology Read More »