November 30, 2020

The Niche

Knoepfler lab stem cell blog

human-animal chimera

2 min read

A new Cell Stem Cell paper by Victoria L. Mascetti and Roger Pedersen on human-mouse chimera modeling is quite interesting and important. I really enjoyed this short paper, but I do have a reservation about one way that it is being interpreted. The authors show that human pluripotent stem cells (hPSC) including induced pluripotent stem cells and embryonic stem cells (hIPSC and hESC, respectively) are pluripotent in vivo during early development. They come to four main conclusions as outlined in their highlights section: •hiPSCs and …Read More

2 min read

Chimeras are one of the more controversial and fascinating areas of human stem cell and early embryo research. The notion of a chimera traces back thousands of years to creatures that were mixtures of various animals including humans in some cases. What about a real human chimera embryo? Today, chimera research has the potential to make major advances in our knowledge and even biomedical treatments such as through human organ creation within animal chimeras. However, human chimera research is intensely divisive amongst society more …Read More