September 28, 2020

The Niche

Knoepfler lab stem cell blog

human chimeras

3 min read

Michael Le Page over at The New Scientist reports on a new paper describing the birth of monkey-piglet chimeras. Unlike most such primate embryo chimeras formed in research in the past, these were allowed to be born. A litter of ten from the new monkey-pig research, two of which were chimeras, all rather quickly died for unknown reasons. Primate chimeras including humans have been much in the news lately. Back in August unpublished work on human-monkey chimeras was also discussed in the press. I am …Read More

3 min read

There’s nothing like stem cell good news and interesting publications to perk one up on a Monday. Enjoy. What recent papers have struck you as exciting? Novel stem cell-based cancer approaches (Part 1) It was exciting when Fate Therapeutics got the first induced pluripotent stem cell (IPSC) IND in the U.S. for their IPSC-derived natural killer cell (NK) product. Now in another milestone the first patient has received the investigational NK therapy at UC San Diego. From UCSD, “After 10 years in remission, Derek Ruff’s cancer …Read More

3 min read

A new paper focused on human and other chimeras just came out today in Cell reporting a number of findings, but most strikingly successful generation of human-pig chimeras in utero. The paper, entitled, “Interspecies Chimerism with Mammalian Pluripotent Stem Cells” describes various chimeras including mouse-rat ones, although those have previously been reported. This work comes from a team led by Juan Carlos Izpisua Belmonte including first author Jun Wu, and also with important contributions from Pablo Ross’s lab here at UC Davis The big news …Read More