October 24, 2020

The Niche

Knoepfler lab stem cell blog

human embryo crispr

6 min read

Is it possible that CRISPR gene editing actually didn’t happen in many of the human embryos in that big Nature paper that made such news a couple weeks back? Some doubts have emerged that call the main conclusions of the paper into question and argue that more definitive studies are needed to be sure. An international team of top scientists led by first author Dieter Egli has responded via a preprint on Biorxiv to that Mitalipov team high-profile Nature paper on CRISPR gene editing of …Read More

2 min read

The human embryo CRISPR paper with Shoukhrat Mitalipov as senior author is coming soon. It will reportedly be focused on the use of CRISPR to genetically modify viable human embryos for reversal of a disease-associated mutation. While strangely press already broke early on this paper last week, as much as a week before the paper comes out, and that press suggests very positive data, how clear will that be from the paper itself? Here are some ideas on the big 5 questions (some include …Read More

6 min read

Cut, modify, paste… It’s kind of a CRISPR mantra for those of us using gene editing in the lab. But it’s supposed to be happening just on DNA, right? Now it appears that someone on a team of human embryo CRISPR researchers possibly got carried away with the cutting-modifying-pasting mindset to take it beyond DNA to also do so with passages of another researcher’s published work that they apparently slightly modified and put into their own paper without any acknowledgement. The 2016 article in question containing plagiarized …Read More

1 min read

This is the second in a series of videos I’m doing where I answer questions about the stem cell field. You can see the Episode 1 video here. Today I tackle more questions on the stem cell field. If you have more stem cell questions, let me know and I’ll try to answer them next time. One reader asked me about stem cells for stroke and about one company, Athersys, in particular, but I haven’t had time to tackle that one in such a way …Read More