human gene editing

National Academies panel leaves door a crack open to future human genetic modification

Early-human-embryos

A National Academies panel on human genome editing chaired by Alta Charo and Richard Hynes released its report today. While it covered both somatic and germline (heritable) human genetic modification, the latter topic is far more contentious. You can see the National Academies summary of their report here. You can read the full report here. …

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Where are all the new CRISPR human embryo papers?

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Last year I heard from several sources that there somewhere between 3-5 unpublished manuscripts reporting the use of CRISPR gene targeting in human embryos being shopped around at various journals in addition to the one that had been published. Since that time we’ve seen a grand total of one additional paper reporting on CRISPR of human …

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Hateful politics infiltrate human genome editing debate in France

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By Elliot Hosman Summary.  A campaign calling for a moratorium on using CRISPR in human embryos was launched by a prominent French organization fighting for narrow understandings of life and family. A recent campaign calling for a ban on “transgenic” human embryos was launched by one of France’s most prominent organizations fighting for “science”-backed “one-man-one-woman” …

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NgAgo a-go-go: main bullet points on upstart CRISPR challenger

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The gene editing technology CRISPR has been arguably the top story in the biomedical world in the last two years, but going forward there is a CRISPR challenger in upstart gene editing technology NgAgo. For more background on NgAgo and the key first published paper on its genetic modification characteristics see my post here.  In the comments on that …

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In Depth Report from April 29th Paris Human Gene Edit Meeting

Paris-Gene-Editing-Meeting

Editor’s note. Caroline Simons attended both the April 28th (see her report on that here) and 29th Paris meetings on human gene editing/genetic modification. Today, we have her in depth report on the April 29th meeting. I have posted her piece in full with only minor edits. If you are in a rush you can …

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Paris human gene editing workshop summary

Académie-Nationale-de-Médicine

Editors note: This is a guest post from Caroline Simons who is attending the two Paris meetings on human gene editing. For more background on those meetings see here. By Caroline Simons There were just over a hundred participants at the workshop organized by the Federation of European Academies of Medicine, the UK Academy of …

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Scoop on this week’s Paris human gene editing/genetic modification meetings

Paris-CRISPR-Meeting

This week there will be two meetings in Paris as part of the ongoing international dialogue on human genetic modification/human gene editing, CRISPR, and figuring out a wise path forward. A one-day workshop will be held on April 28th “jointly organised by the Federation of European Academies of Medicine (FEAM), the UK Academy of Medical …

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New Paper on CRISPR of Human Embryos Highlights Serious Tech Problems

Human-embryo-CRISPR

A new paper was recently published on CRISPR of human embryos for genetic modification. I’ve got to read this publication more carefully, but here’s a quick initial take on this human CRISPR 2.0 study. The paper is Kang, et al. and is entitled “Introducing precise genetic modifications into human 3PN embryos by CRISPR/Cas-mediated genome editing”. …

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You can’t retract a designer baby: #CRISPR, social justice, & risks

CRISPR-baby-retraction

There’s a questionable notion floating around out there in the numerous discussions over heritable human genetic modification. This idea goes that if germline human gene editing goes awry for any number of reasons, scientists could simply reverse it by applying genetics again. The reversal notion does not fit with the reality of science as we …

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Follow up Gene Editing Meeting to be Held in Paris in April on Human CRISPR

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Back in December, the US National Academies held a first of its kind meeting on human gene editing. Keeping the dialogue going, there is a follow up meeting planned for April 29 in Paris, France. The Paris meeting is described this way: “Upcoming Public Meeting in Paris The consensus committee will host a public meeting …

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