October 24, 2020

The Niche

Knoepfler lab stem cell blog

human genetic modification

15 min read

I talked last year about human genetic modification by CRISPR with George Church a year ago. Now we’ve followed up with a long chat on this topic going into much more detail and with questions on recent developments. Each question is listed numerically and then there is a back and forth on that question with George and me before going on to the next question. Frameworks for managing human genetic modification 1. Paul: What do you think of my ABCD plan for handling human germline …Read More

3 min read

A new paper was recently published on CRISPR of human embryos for genetic modification. I’ve got to read this publication more carefully, but here’s a quick initial take on this human CRISPR 2.0 study. The paper is Kang, et al. and is entitled “Introducing precise genetic modifications into human 3PN embryos by CRISPR/Cas-mediated genome editing”. This is only the second paper reporting genetic modification of human embryos. The first paper, also from China, created quite a stir last year and reported a lot of technical …Read More

2 min read

I like Easter eggs, science and writing, and Easter is less than a week away. I also think that games and puzzles as well as contests where there are prizes are fun. In this spirit I’ve hidden a scientific Easter egg inside of my new book, GMO Sapiens. If you are the first to find it and notify me, I will give you a $250 prize. We are talking about a scientific Easter egg. Wikipedia defines this sort of Easter egg this way: “An Easter egg is …Read More