October 24, 2020

The Niche

Knoepfler lab stem cell blog

human germ cell gene editing

4 min read

Hank Greely over at The Center for Law and Biosciences at Stanford Law School was one of the participants in the recent Napa meeting on approaches to human germline genetic modification. Hank was also one of the authors on the resulting position paper in Science with David Baltimore as first author (here). Now Hank, pictured below, has written an intriguing blog post that kind of gives a behind the scenes look at what has gone on in this area in the last few months and …Read More

2 min read

We’ve all heard the human embryo editing rumors. There is a sense that human embryos have already been CRISPR’d. Rumors are rumors and they may mean not a whole lot, but there definitely is a huge buzz on this right now both in a positive sense and with concern. The excitement is over the power of this technology to do transformative things. The worry is that these papers might easily cross a line or if they are not done incredibly rigorously with unquestionable transparency, institutional …Read More

3 min read

Should we be using the term ‘genetically modified human’ in discussions of heritable use of CRISPR in people? During the still ongoing discussions of genetic modification in the human germline and potentially in actual human beings in the future, an interesting, but difficult question has emerged: What words or names would be most appropriate for the community to use to refer to potential future human beings that have gene edits? I have up until now referred to such hypothetical people as “genetically modified humans” or …Read More

3 min read

CRISPR Cas9 gene editing technology is a game changer on many levels both inside and soon outside the lab. There is a growing sense of urgency amongst biomedical scientists to take a proactive approach to current and future use of CRISPR gene editing technology in human germ cells and embryos. These concerns have been heightened by rumors of multiple papers currently in various stages of peer review that will reportedly describe CRISPR-mediated gene editing of human embryos. A number of scientists and scientific organizations have recently come …Read More