June 1, 2020

The Niche

Knoepfler lab stem cell blog

human germline editing

3 min read

When I say “gene edit” or “genome editing”, what’s the first thing that pops in your mind? It will depend on who you are. For many lay people until a few weeks ago when the world heard about He Jiankui‘s claim of CRISPR’d babies they may not have had anything pop in their heads when hearing “gene editing.” Now perhaps they think of babies bearing specific genetic changes. I bet most of them who think that way today are envisioning that He made very …Read More

4 min read

Did Chinese researcher He Jiankui really CRISPR gene edit the CCR5 gene in two embryos producing twin baby girls? In my opinion the answer is “no”, but probably not for the reason you might think at first. He proclaims gene edits He claimed he had made twin baby girls with “gene edits”, which I feel is unethical overall and risky to those babies. He’s announcement also may have been intentionally timed to occur right before an international meeting on human gene (or genome) editing last week …Read More

1 min read

Heritable CRISPR to be tried in humans sooner or later…or never? Will someone somewhere in the world try to use CRISPR gene editing or related technology to introduce heritable genetic changes into actual human beings in the next decade? I’m not talking about gene editing viable human embryos just for research which is already ongoing, but rather CRISPR’ing human embryos to then use to try to make babies who grow up to be adult humans with a specific genetic change. How likely is this? Take …Read More