November 29, 2020

The Niche

Knoepfler lab stem cell blog

human-mouse chimera

2 min read

A new Cell Stem Cell paper by Victoria L. Mascetti and Roger Pedersen on human-mouse chimera modeling is quite interesting and important. I really enjoyed this short paper, but I do have a reservation about one way that it is being interpreted. The authors show that human pluripotent stem cells (hPSC) including induced pluripotent stem cells and embryonic stem cells (hIPSC and hESC, respectively) are pluripotent in vivo during early development. They come to four main conclusions as outlined in their highlights section: •hiPSCs and …Read More