May 31, 2020

The Niche

Knoepfler lab stem cell blog

Human reproductive cloning

4 min read

It was intriguing last week to read about another advance in somatic cell nuclear transfer (SCNT)-based therapeutic cloning of human embryonic stem cells (hESC). The first such work was published last year by Mitalipov’s group from OHSU. This second paper to produce so-called nuclear transfer hESC (NT-hESC) made the important advance to show that it could be done using adult and even old human somatic cells. This is a reproducible technology, which is very important. However, key challenges and concerns remain for human therapeutic cloning …Read More

3 min read

What was the biggest news story of the year in the stem cell world? There have been many interesting developments in stem cells in 2013, but to me the biggest event by far was the first ever successful somatic cell nuclear transfer (SCNT)-based human therapeutic cloning. This approach generated apparently genetically normal human embryonic stem cells (hESC), an astonishing accomplishment. There are two kinds of human cloning: therapeutic and reproductive. The latter is making an actual new person with an identical genome to an existing …Read More

2 min read

Human cloning is not so far-fetched any more.  Cloning of the Star Wars variety where new copies of people (although they would be babies, not adults of course at first) are produced is something I believe that we’ll see in the next 1-2 decades. Why would anyone bother to clone? Fame. Money. Vanity. There are many reasons, all bad in my opinion. Then there is the possibility that human cloning could produce babies for infertile couples. Should human cloning be allowed in the future …Read More

2 min read

People have been confused about human cloning issues in the last few weeks on a number of levels. The confusion has come along with the excitement, concern, and increased interest in cloning lately since the lab of Dr. Shoukhrat Mitalipov reported a few weeks back in Cell the astonishing feat of successful human embryonic stem cell cloning by somatic cell nuclear transfer (SCNT), a watershed moment for the stem cell field. One area that people seemed confused about is just who is in favor …Read More

1 min read

Human cloning is an important issue at both scientific and societal levels. Earlier I included a guest post from bioethicist, Arthur Caplan, on human cloning. Today I am posting a short Q&A with Nobel Laureate John Gurdon. I asked Gurdon three specific questions and below each I have listed his answer. My sense is that he is not very enthusiastic about the idea of human reproductive cloning. 1.) Assuming technological issues are overcome, do you see human cloning (and by this I mean reproductive …Read More

3 min read

Note that this is the first in a series of guest posts and interviews on human reproductive cloning. Next will be an interview with Nobel Laureate John Gurdon. By Arthur Caplan The issue of human cloning for reproduction is one of the greatest non-issues in the history of ethical disputes in America and around the world. Most objections to trying to make clones pivot on safety for the clone. And that is certainly a big deterrent to cloning. 
Cloning is dangerous as outcomes in …Read More