January 25, 2021

The Niche

Trusted stem cell blog & resources

Ignacio Sancho-Martinez

5 min read

Can hearts repair themselves via their own stem cells? Science evolves Sometimes what we scientists all know to be true turns out later on to be wrong and there are clear instances of this in the stem cell field. For example for decades the dogma was that the adult mammalian brain did not have stem cells, but now most researchers believe that the adult brain does have stem cells, although for humans this is still being debated. What we perceive as factual can change over time. Yamanaka …Read More

5 min read

The Juan Carlos Izpisua Belmonte group published a Cell paper today on using gene editing to reverse mutations associated with human mitochondrial disease. The paper is Reddy, et al. and is entitled, “Selective Elimination of Mitochondrial Mutations in the Germline by Genome Editing”. The authors report success using TALEN-based gene editing or mitochondrial-direct restriction enzyme (mito-ApaLI) to reduce the burden of mutant mitochondrial DNA (mtDNA). Their work was done primarily in mice, but also using chimeras made with murine oocytes fused with human cells bearing …Read More