July 11, 2020

The Niche

Knoepfler lab stem cell blog

Insoo Hyun

2 min read

In this post I list some recent interesting stem cell and science pubs including artificial human embryo research. Engineered human embryo research continues. Scientists for years have been advancing the types of embryo-like structures made from both human and other creature’s cells. In a new Nature Cell Bio pub entitled, “A 3D model of a human epiblast reveals BMP4-driven symmetry breaking”, a team led by Eric Siggia pushed this further. See an image from the paper I’ve included that shows signs of the primitive …Read More

4 min read

Is monkey cloning a good idea? We’re about to find out. A new Cell paper today reports the first cloning of monkeys via somatic cell nuclear transfer (SCNT), raising many questions. The paper from a team led by Qiang Sun is entitled, “Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer.” The highlight bullet points from the paper are the following: “•Somatic cell nuclear transfer (SCNT) using fetal fibroblasts yielded two live monkeys •Epigenetic modulators promoted development and pregnancy rate of SCNT embryos •SCNT …Read More

1 min read

Here are some stem cell reads for the weekend, ranging from media to research articles. TGIF! What are your stem cell or other science weekend reads? Let’s start with how difficult it is to make IPS cells from naked mole rats! Naked Mole Rat Cells Have a Stable Epigenome that Resists iPSC Reprogramming. It takes more than OSKM to make naked mole rat IPSCs. Throwing in SV40 LT helps, etc. Regeneration is cool & we are getting to understand it better, Study first to identify the cells …Read More

3 min read

A committee of the International Society for Stem Cell Research (ISSCR) did one heck of a document dump yesterday on stem cell policy, releasing a whole bunch of policy recommendations on stem cells and more. The torrent from ISSCR included a 37-page policy statement itself as well as several papers in top journals including the Lancet, Science, and Nature. This output was the product of the members of a special  ISSCR Task Force, whose members I have listed at the bottom of this post. Who …Read More