Can cells produced from autologous induced pluripotent stem cell (IPSC or IPS cell) cultures sometimes be immunogenic in patients? This key question has remained somewhat unsettled due to varied findings over the years (e.g. see here), but many of us had generally felt in the last couple years that IPS cell derivative immunogenicity in an autologous context wouldn’t be a major problem. This is a big deal because if human IPS cell cultures and in particular their derivatives are immunogenic (sparking a major immune …Read More
I recently did a series of 4 polls on potential roadblock issues in the iPS cell field. The impetus for these polls was my sense that there were substantial differences in views on whether iPS cells were now proven to be equivalent to ES cells in 4 key ways. Turns out the polls got a good number of respondents and revealed some clear insight into people’s views of the seeming major iPS cell issues of the past few years and currently. One of the …Read More
Just how good are today’s iPS cells? Are they essentially functionally the same as ES cells? Take our polls below to let us know your thoughts.