iPS cell immunogenicity

IPS Cell Immunogenicity, Clinical Insights, & Possible Solutions

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Can cells produced from autologous induced pluripotent stem cell (IPSC or IPS cell) cultures sometimes be immunogenic in patients? This key question has remained somewhat unsettled due to varied findings over the years (e.g. see here), but many of us had generally felt in the last couple years that IPS cell derivative immunogenicity in an …

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New iPS cell conventional wisdom from polls: epigenetics & mutations remain concerns, immunogenicity not so much

I recently did a series of 4 polls on potential roadblock issues in the iPS cell field. The impetus for these polls was my sense that there were substantial differences in views on whether iPS cells were now proven to be equivalent to ES cells in 4 key ways. Turns out the polls got a …

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