September 29, 2020

The Niche

Knoepfler lab stem cell blog

iPS cell mutations

2 min read

Over the years some scientists including yours truly have expressed concerns about the possibility that mutations could crop up during the reprogramming process to make induced pluripotent stem cells (IPS cells or IPSC). How concerned should we be about IPS cell mutations? A cool new paper, Bhutani, et al, in Nature Communications from a team led by Jeanne Loring and Nicholas J. Schork presents data arguing against significant oncogenic mutations occurring during reprogramming to make IPSC. The authors summarize their findings this way: “Our results show a moderate …Read More

2 min read

I recently did a series of 4 polls on potential roadblock issues in the iPS cell field. The impetus for these polls was my sense that there were substantial differences in views on whether iPS cells were now proven to be equivalent to ES cells in 4 key ways. Turns out the polls got a good number of respondents and revealed some clear insight into people’s views of the seeming major iPS cell issues of the past few years and currently. One of the …Read More