October 1, 2020

The Niche

Knoepfler lab stem cell blog

IPS cells versus ES cells

4 min read

Has it really been 10 years since induced pluripotent stem cells (aka IPS cells or IPSC) came onto the scene in the stem cell field? Yes, it was a decade ago that now Nobel Laureate Shinya Yamanaka (山中伸弥) published that seminal Cell paper on reprogramming to make mouse IPS cells and then human IPS cells came the next year. From the moment I read that first mouse IPS cell paper, I was very excited about the science and the ideas in it. The domain …Read More

3 min read

Update in 2020: It seems now after all these years that the consensus in the now more mature field is that IPSCs and ESCs are nearly identical in most cases, and both have some of the same translational challenges such as teratoma-forming activity. It’s interesting to read this post from nearly 10 years ago and the concerns that were so intense back then. An important question in the young iPS cell field has been– just how similar these reprogrammed iPS cells are to embryonic …Read More