October 25, 2020

The Niche

Knoepfler lab stem cell blog

IPS cells without Myc

3 min read

Yamanaka may have found a way to give exogenous Myc the boot from the iPS cell universe. It has always been a frustration in the iPS cell field that Myc, a proto-oncogene, is so important for reprogramming. Yes, you can make iPS cells (especially mouse) without Myc, but it can be orders of magnitude harder, especially when making human iPS cells.  And if you end up with just a little bit too much Myc, the cells can become cancerous. While Myc may not be …Read More