iPS cells

Landmark: patient receives first ever iPS cell based transplant

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In a major first for the stem cell and regenerative medicine fields, a patient in Japan today received a pioneering transplant of a retinal pigmented epithelial (RPE) sheet made from induced pluripotent stem (iPS) cells, also known by the acronym IPSC. This is the first ever iPS cell-based transplant into a human. The patient is …

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Key questions for stem cell field bouncing around on a Friday morning

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What are the most interesting questions for the stem cell field in 2014 right now? What’s on your mind? I’m not going to give this deep thought, but rather just list those questions bouncing around at the moment in no particular order. You can see a lot of translational/clinical things are on my mind. I’ve …

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Masayo Takahashi Interview on iPS cells, clinical studies, & more

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In the interview below I talk with Dr. Masayo Takahashi, who is leading a team conducting the first ever in-human clinical study based on iPS cells. The work began with patient enrollment on Aug. 1, 2013 in Japan. 1. Can you tell us a bit about your background? As an M.D./Ph.D. and ophthalmologist do you …

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Jailbreak Cell Fate to Reprogram Stem Cells

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You can jailbreak your iPhone, but perhaps you can jailbreak a cell too to turn it into a stem cell. In his very cool talk up here at the Till & McCulloch Meeting on Stem Cells yesterday, Andras Nagy characterized the reprogramming process to make iPS cells as “jailbreaking” cell fate. Nagy described some intriguing studies done on …

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Japan Aiming For a Commanding Position on New Stem Cells

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Stem cell technology is poised to wow the world with biomedical advances in the coming decades and Japan wants to lead the way. They want to forge ahead particularly with applications that focus on a relatively new kind of stem cells called induced pluripotent stem cells or iPS cells. Japanese researcher, Shinya Yamanaka, first reported production …

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Stem cell field mostly taking a wait-and-see attitude toward all chemical reprogramming to make iPS cells

I recently did a poll on people’s reactions to the new paper reporting use an all-chemical approach to making iPS cells through cellular reprogramming. I got a good number of responses relatively quickly. The results so far suggest that by far most people think it is too soon to know the importance of this new …

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What do you think of all chemical reprogramming? Take our poll

How important is the new development of all chemical reprogramming to make iPS cells? The group led by Hongkui Deng at Peking University in Beijing reported in Science that they used 7 chemicals to make what appear to be mouse iPS cells. I’m hearing a wide range of opinions directly from people in the know. What’s …

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FDA & Japanese Health Ministry (厚生労働省) To Develop Joint iPS cell clinical rules by 2015 while first human studies to begin earlier in 2014

In a rare sign of stem cell international regulatory unity, the Japanese Health Ministry (厚生労働省) and the US FDA have agreed to develop a joint, unified regulatory framework for clinical studies of human iPS cells for use in treating retinal diseases. Presumably the rules would also guide clinical use of iPS cells to treat other …

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Janet Rossant, ISSCR President, on her goals, cloning, non-compliant clinics, iPS cells, and future of field

New ISSCR President, Dr. Janet Rossant, kindly agreed to do an interview with me focused on the future of ISSCR, her plans for her tenure, and some key issues in the field. Dr. Rossant is Chief of Research at The Hospital for Sick Children in Toronto. 1. The stem cell arena is a very rapidly changing one …

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Asahi Shimbun Editorial: iPS Cells Rushed For Economic Reasons

In a shocker, Japan’s 2nd largest newspaper, Asahi Shimbun, published an editorial yesterday  saying that iPS cells are being pushed too fast to the clinic for economic reasons. The piece was bluntly entitled “Too much of a rush for clinical trials with iPS cells”. Asahi Shimbun, with a circulation of 10 million, is taking a bold …

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