July 12, 2020

The Niche

Knoepfler lab stem cell blog

iPS cells

5 min read

Every year I look into my stem cell crystal ball and make a top 10 list of stem cell predictions for the coming year. My predictions for 2015 will be coming up soon and I may bump them up to 20 predictions instead of 10 because there’s so much going on in the field. Stay tuned. If you are curious, you can read my past top predictions for 2011, 2012 and 2013. You can also see how much the stem cell field has changed based on these …Read More

3 min read

How cool is it that literally fuzzy new stem cells called “F-class cells” bring substantial new sharp focus to the cellular reprograming arena? Remember Project Grandiose led by the great stem cell scientist Andras Nagy? It’s a massive project intended to decipher what makes stem cells tick and how ordinary cells be changed or reprogrammed into powerful pluripotent stem cells that can make any other type of cell. I’ve heard Nagy speak before about it at meetings and this blog first reported on these fuzzy cells …Read More

7 min read

It’s a particularly exciting time for the stem cell field. One of the most notable developments in the last year or so is the production and preliminary study of a totally new type of human embryonic stem cells (ESC) made by nuclear transfer instead of using leftover in vitro fertilization (IVF) embryos. This process of so-called therapeutic cloning has the power to produce patient specific ESCs called NT-ESCs that can in principle be used in the future for autologous transplants for a number of diseases …Read More

3 min read

In a major first for the stem cell and regenerative medicine fields, a patient in Japan today received a pioneering transplant of a retinal pigmented epithelial (RPE) sheet made from induced pluripotent stem (iPS) cells, also known by the acronym IPSC. This is the first ever iPS cell-based transplant into a human. The patient is reported to be a 70-something Japanese woman suffering from macular degeneration and the procedure was performed by Dr. Yasuo Kurimoto and other specialists. I highly recommend the article by …Read More