July 12, 2020

The Niche

Knoepfler lab stem cell blog

iPS cells

2 min read

What are the most interesting questions for the stem cell field in 2014 right now? What’s on your mind? I’m not going to give this deep thought, but rather just list those questions bouncing around at the moment in no particular order. You can see a lot of translational/clinical things are on my mind. I’ve put possible answers, but these are highly speculative and/or based on hope in some cases. What’s next for ACT’s hESC-based clinical trials and Takahashi’s iPS cell-based clinical study for macular …Read More

5 min read

In the interview below I talk with Dr. Masayo Takahashi, who is leading a team conducting the first ever in-human clinical study based on iPS cells. The work began with patient enrollment on Aug. 1, 2013 in Japan. 1. Can you tell us a bit about your background? As an M.D./Ph.D. and ophthalmologist do you also see patients in addition to doing research? How did you first get interested in stem cells? Are your interests primarily in iPS cells? Yes, I have outpatient clinics in …Read More

3 min read

You can jailbreak your iPhone, but perhaps you can jailbreak a cell too to turn it into a stem cell. In his very cool talk up here at the Till & McCulloch Meeting on Stem Cells yesterday, Andras Nagy characterized the reprogramming process to make iPS cells as “jailbreaking” cell fate. Nagy described some intriguing studies done on reprogramming by his lab together in collaboration with an international consortium. I especially appreciated the fact that Nagy (see pic at left, credit to Peter Raaymakers) tackled head on …Read More

3 min read

Stem cell technology is poised to wow the world with biomedical advances in the coming decades. Japan wants to lead the way, particularly with applications that focus on a relatively new kind of stem cells called induced pluripotent stem cells or iPS cells. Japanese researcher, Shinya Yamanaka, first reported production of iPS cells in 2006 in mice and in 2007 in humans. Japan has raced ahead of other countries and they appear to have the intellectual property rights and drive to do so. And …Read More