July 11, 2020

The Niche

Knoepfler lab stem cell blog

IPSC immunogenicity

3 min read

Can cells produced from autologous induced pluripotent stem cell (IPSC or IPS cell) cultures sometimes be immunogenic in patients? This key question has remained somewhat unsettled due to varied findings over the years (e.g. see here), but many of us had generally felt in the last couple years that IPS cell derivative immunogenicity in an autologous context wouldn’t be a major problem. This is a big deal because if human IPS cell cultures and in particular their derivatives are immunogenic (sparking a major immune …Read More