IPSC

Silva Comments on MBD3/NuRD Debate with Jacob Hanna

Jose-Silva

What’s the deal with the tension between José Silva and Jacob Hanna over pluripotency? Researchers probing how to reprogram cells into powerful stem cells (induced pluripotent stem cells or IPSCs) and what the molecular mechanisms are behind this process have become entangled in a conflict. Of course over the years scientists including stem cell scientists have …

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Fuzzy New Stem Cells Bring Reprogramming into Focus

F-class-stem-cells

How cool is it that literally fuzzy new stem cells called “F-class cells” bring substantial new sharp focus to the cellular reprograming arena? Remember Project Grandiose led by the great stem cell scientist Andras Nagy? It’s a massive project intended to decipher what makes stem cells tick and how ordinary cells be changed or reprogrammed into powerful …

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Dieter Egli Interview: NT-ES cells, IPSC, Mitochondrial Transfer, & More

Dieter_Egli

It’s a particularly exciting time for the stem cell field. One of the most notable developments in the last year or so is the production and preliminary study of a totally new type of human embryonic stem cells (ESC) made by nuclear transfer instead of using leftover in vitro fertilization (IVF) embryos. This process of so-called …

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Future of Somatic Cell Nuclear Transfer to make ES Cells

NT-ESC-versus-IPSC

Advances in therapeutic cloning reported in the past year have been very exciting as somatic cell nuclear transfer (SCNT) can be used to produce very powerful human embryonic stem cells (ESC). These new cells are called NT-ESCs for short. Neither embryos nor reprogramming factors are needed to produce human NT-ESCs. See here, here and here for discussions of the pioneering papers reporting creation of …

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Yamanaka Interview on Clinical Use of IPSC

Dr.-ShinyaYamanaka

I invited Nobel Laureate Shinya Yamanaka to do an interview on the future of clinical translation of induced pluripotent stem cells (iPSC). He provides some intriguing new insights into the iPSC field and the broader stem cell arena. PK: The Takahashi Team’s active Clinical Study using iPSCs to make RPEs to treat Macular Degeneration has …

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Advanced Cell Technology pub: Trial for Macular Degeneration

ACT-FIgure-1-

The stem cell biotech Advanced Cell Technology (ACT) reported new, positive data in a paper in Lancet from their clinical trials using retinal pigmented epithelial cells (RPEs) made from human embryonic stem cells (hESC) for treatment of different forms of macular degeneration (MD). The paper was entitled “Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related …

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