September 19, 2020

The Niche

Knoepfler lab stem cell blog

Jacob Hanna

1 min read

Papers and news for weekend reads. Hostile Takeover: Glioma Stem Cells Recruit TAMs to Support Tumor Progression by Yu Shi, Yi-fang Ping, Xia Zhang, Xiu-wu Bian in Cell Stem Cell YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate self-renewal and Vascular Mimicry of Stem-like Cells by Namrata Bora-Singhal, Jonathan Nguyen, Courtney Schaal, Deepak Perumal, Sandeep Singh, Domenico Coppola, Srikumar Chellappan in Stem Cells Jacob Hannah’s team posts on bioRxiv in support of their original Mbd3/NuRD findings. RetractionWatch: Judge rules most of PubPeer’s commenters can remain anonymous. The key …Read More

4 min read

A question that has come up with advances in stem cell technology: could same-sex couples have their own biological children? Since Shinya Yamanaka reprogrammed first mouse and then human ordinary cells into powerful pluripotent stem cells, termed induced pluripotent stem (iPS) cells, back in 2006-2007 many new research avenues have opened up. The impossible suddenly seemed a lot more possible with the report of iPS cells (aka IPSC). People started asking many more creative questions, The biomedical sciences now had more potential to make the …Read More

4 min read

What’s the deal with the tension between José Silva and Jacob Hanna over pluripotency? Researchers probing how to reprogram cells into powerful stem cells (induced pluripotent stem cells or IPSCs) and what the molecular mechanisms are behind this process have become entangled in a conflict. Of course over the years scientists including stem cell scientists have had their share of disagreements and debates in the past including heated ones, but this reprogramming clash has taken it up a notch beyond past ones and has some unique elements …Read More

1 min read

TGIF: I’m working on an R01, but I still try to find time to read a wide variety of papers. Below are the science pubs that I’m hoping to get to this weekend. Less Myc, longer “health span” Cell paper from Sedivy Lab. ESC Histone H3.3 nucleosomal functions Epigenetics & Chromatin paper from Keji Zhao Lab. Human PGC specification Cell paper from Jacob Hanna Lab. SETDB1 & hnRNP K tango to silence ERVs in ESCs PLOS Genetics paper from Matt Lorincz Lab. Novel antibiotic isolated from …Read More