August 7, 2020

The Niche

Knoepfler lab stem cell blog

John Gurdon

4 min read

A relatively newly recognized, important player in the stem cell field is a molecule called histone variant H3.3. Histones are key components of chromatin with integral roles in regulating almost all aspects of cell behavior through orchestrating functions such as transcription and chromosome segregation. My lab has just (April 9) published new studies on histone H3.3, the first of their kind on the endogenous histone H3.3 protein in mammals. The work was supported by CIRM and NIH. Much of our work was based on …Read More

3 min read

Below, guest blogger, John Carbona gives us his account (including pictures) of Day 2 of the Vatican Stem Cell Meeting, which included a talk by Nobel Laureate John Gurdon. Note, you can read John’s post on Day 1 of the meeting including more great pictures here. Friday, April 12, 2012 The Second International Vatican Adult Stem Cell Conference: Regenerative Medicine – A Fundamental Shift in Science & Culture, taking place from within The Vatican Last night was a magical evening for this former altar …Read More

1 min read

Human cloning is an important issue at both scientific and societal levels. Earlier I included a guest post from bioethicist, Arthur Caplan, on human cloning. Today I am posting a short Q&A with Nobel Laureate John Gurdon. I asked Gurdon three specific questions and below each I have listed his answer. My sense is that he is not very enthusiastic about the idea of human reproductive cloning. 1.) Assuming technological issues are overcome, do you see human cloning (and by this I mean reproductive …Read More

2 min read

Stem cell revolutionaries Drs. Shinya Yamanaka and John Gurdon have won the 2012 Nobel Prize for Physiology or Medicine. Gurdon cloned for the first animal, a frog, and Yamanaka produced induced pluripotent stem cells (iPSCs), a kind of stem cell with the power of pluripotency, but derived from ordinary non-stem cells. Gurdon’s work was based on the technique of nuclear reprogramming based on somatic cell nuclear transfer (SCNT). Both men are well-deserved winners of the Nobel Prize for their work investigating how cell fate …Read More