October 31, 2020

The Niche

Knoepfler lab stem cell blog

Lorenz Studer

3 min read

In Parkinson’s Disease patients develop neurological dysfunction as they lose a special kind of brain cell called dopaminergic (or dopamine) neurons. While a number of different approaches to this disease have been studied for decades, nothing has proven particularly successful in slowing its progression. As a result there has been a big need for novel thinking about how to tackle Parkinson’s Disease including via stem cells. One of the most exciting ideas has been to use human induced pluripotent stem cells (hIPSC) or human embryonic …Read More

5 min read

Every year in December I go out onto a limb and make stem cell predictions for the coming year as I did in late 2017 for this year. Then usually around the 1/2-way point through the year I check in on how the predictions are faring so far at that point. In this post I give my 2018 predictions (pasted below) the 1/2-way point checkup. Things are off to a reasonably strong start for the old stem cell crystal ball.  For the grading, green is …Read More

2 min read

One of the highlights of Day 1 of #ISSCR2018 for me so far was the talk by Lorenz Studer (Co-Founder of BlueRock) on the use of human embryonic stem cell (HESC)-derived dopamine neurons for Parkinson’s Disease. Note that for this post and if I have time any others on this meeting, they are probably going to be somewhat stream of consciousness notes from the talks and may have some outlined points rather than sentences. I have some questions or notes for myself that I …Read More

2 min read

One of the most famous living biological scientists, Sir Ian Wilmut, just announced that he has Parkinson’s Disease. I wish him the best in dealing with this illness. Wilmut is very well-known for having cloned the first mammal, Dolly the Sheep. This work followed on the earlier breakthrough by Sir John Gurdon of cloning the first vertebrate with his work in frogs. it just occurred to me: I’m not sure if the first cloned frog had a name! Over the years there has been …Read More