September 25, 2020

The Niche

Knoepfler lab stem cell blog

Mahdi Lamb

3 min read

Today a new Nature paper from Dr. Mary Herbert’s group in the UK has found a key problem with mitochondrial replacement therapy that fits with data from others. The goal of preventing mitochondrial disease using various kinds of genome transfer technologies is a noble one, but mitochondrial replacement therapy has faced a number of technological challenges including perhaps most prominently the carryover and subsequent amplification of diseased mitochondria. This mitochondrial replacement carryover issue was clearly defined in an excellent recent Cell Stem Cell paper …Read More