October 28, 2020

The Niche

Knoepfler lab stem cell blog

Marcy Darnovksy

4 min read

It’s an odd confluence of events this week that (A) the Nuffield Council, an ethics think tank, gives a thumbs up in a new report to heritable human genetic modification that would probably include using CRISPR in the same week that (B) a new paper reports that CRISPR can cause unpredictable genomic damage and several other concerning reports about possible CRISPR technology side effects or challenges have come out in the last few months. Talk about bad timing. They would probably counter my intro paragraph by saying …Read More

4 min read

Today we got the first report of a baby being born via so-called “3-person IVF”, sometimes called 3-parent IVF, in which the DNA of three people contribute to an offspring. Before discussing this further I have to emphasize that we need proof that this is indeed really a 3-person IVF baby via genetic testing. Until that data is released publicly we should all be cautious on this news. Apparently the clinic plans to present such data later. Assuming it is a 3-person IVF baby, which …Read More

1 min read

It’s been a busy few weeks for the CRISPR arena so I’ve made a CRISPR Update. I’ve listed below links to some commentaries and key developments.   Fun Video interview on Read Science! with Joanne Manaster on my new book on CRISPR in humans, GMO Sapiens. CRISPR: Pursuit of profit poisons collaboration, Nature piece by Jacob Sherkow HIV Fights Off CRISPR Gene-Editing Attack. HIV adapts when CRISPR attacks. 2nd group CRISPR’s human embryos and things don’t go well. More Indels than precise gene edits, mosaicism and …Read More