MUltilineage-differentiating Stress-Enduring cells

Dubious MUSE cells are in 4 Japanese stem cell trials

November 17, 2019 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 14 Comments

Professor-Mari-Dezawa-talking-about-MUSE-cells-on-national-TV-in-Japan.-Screenshot.

The stem cell universe is populated by sometimes mysterious acronyms (see an image of a whole alphabet stem cell acronym soup), many of which refer to specific kinds of stem cells including one nebulous type called MUSE cells. I’m not convinced that MUSE cells exist, but oddly there appear to be four clinical trials ongoing …

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Jury is still out on purported adult pluripotent stem cells despite new MUSE paper

June 6, 2013 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 14 Comments

Are MUSE cells for real? Stem cells come in different types that vary in a key property called “potency”, but very few are pluripotent. The more potency, the greater the flexibility of a stem cell to make other cell types. Flexibility in the cellular world is power. The most powerful stem cells generally used are …

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