September 25, 2020

The Niche

Knoepfler lab stem cell blog

MUSE stem cells

2 min read

Now that it appears that the authors have all consented to eventually have both of their STAP cell Nature papers retracted, what’s next for STAP? Who knows, but below is my attempt at a top 10 list of STAP predictions looking ahead. I hope I’m wrong about several of them. 10. No insight will come from Nature on the STAP review or editorial process and there will be no indication from them that anything went wrong at their level.  I predict the journal will …Read More

2 min read

Japanese news media are reporting that Haruko Obokata and other key authors have agreed to retract the Nature STAP cell letter, but not the Nature article. This is a major development and a peculiar one because to many in the  field it is the Nature STAP cell article that is the more flawed of the two Nature papers on STAP. Why would Obokata and her colleagues agree to retract the STAP letter from Nature, especially after for so long categorically rejecting the idea? I suspect they are under pressure from other …Read More

3 min read

Two stem cell papers riddled with errors, with figures that resulted from potential misconduct, with plagiarism, and with other serious problems remain uncorrected and unretracted in the prestigious journal Nature. It is well past time for the journal to editorially retract them. It was about four months ago that Nature published the two astonishing STAP papers reporting the supposed creation of super-powerful stem cells (known variously as STAP cells or STAP stem cells) via simple methods such as weak acid treatment. Since their publication, it’s been all …Read More

4 min read

Are MUSE cells for real? Stem cells come in different types that vary in a key property called “potency”, but very few are pluripotent. The more potency, the greater the flexibility of a stem cell to make other cell types. Flexibility in the cellular world is power. The most powerful stem cells generally used are called “pluripotent”, which refers to a special kind of stem cell that can make all 200+ other types of cells in the body through differentiation. Pluripotent stem cells are hard …Read More