September 29, 2020

The Niche

Knoepfler lab stem cell blog

MYBPC3

4 min read

Remember that Shoukhrat Mitalipov lab paper on the use of CRISPR in human embryos? It’s back in the news. One of the biggest stories of 2017 centered on a Nature paper (Ma, et al., see my quick, initial review shortly after it was published here) from Mitalipov’s lab claiming both efficient repair of a disease-causing mutation in human embryos via CRISPR-Cas9 gene editing and that the correction happened at the MYBPC3 gene via an unexpected mechanism using the normal maternal chromosome as a template (the …Read More

5 min read

We can be confident that human genetic modification via CRISPR’ing of embryos soon will be safe and effective after that new exciting Mitalipov team paper, right? Wrong. The reality is far more complicated and interesting on the tech side. In a nutshell, I see the paper as a significant scientific, but not necessarily medical advance. The media coverage overall has painted too rosy and simplistic a picture of the Mitalipov paper. Setting aside tough bioethical and societal issues regarding human genetic modification for the …Read More