MYC

Probing Nature pub’s puzzling claim of brain cells globetrotting into prostate tumors

Mauffrey-Nature-Prostate-Neural-invasion-2019-Fig-3ce

A new Nature paper makes the striking claim that neural precursor cells of the brain migrate all the way to prostate tumors. Furthermore, the team led by Claire Magnon claims that these long-distance cellular travelers from the brain not only take up residence in the prostate but also strongly drive progression of the prostate cancer …

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Quick journal club on IPSC anti-aging paper: cool, but outstanding questions

IPSC-anti-aging-paper

A new Cell paper from Juan Carlos Izpisua Berlmonte’s group has made headlines about anti-aging across the globe because it suggests that the four core induced pluripotent stem cell (IPSC) factors use by Shinya Yamanaka to make IPSC can reverse aging. I’ve pasted the graphical abstract from the paper below and done a quick journal club style …

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Tumorigenicity and Pluripotency teased apart? Not yet for Myc

Fig.-5-Nakagawa-et-al.-Myc-in-cancer-and-IPScs

A paper just came out in PNAS entitled “Promotion of direct reprogramming by transformation-deficient Myc“. The main thrust of this paper is that the tumorigenic and pluripotency-related functions of Myc could be separated. It focused primarily on the lesser studied LMyc. The topic of the intertwined good (pluripotency) and bad (tumorigenicity) functions of Myc, addressed …

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