MYC Archives - The Niche

Probing Nature pub’s puzzling claim of brain cells globetrotting into prostate tumors

May 19, 2019 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 8 Comments

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A new Nature paper makes the striking claim that neural precursor cells of the brain migrate all the way to prostate tumors. Furthermore, the team led by Claire Magnon claims that these long-distance cellular travelers from the brain not only take up residence in the prostate but also strongly drive progression of the prostate cancer …

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Quick journal club on IPSC anti-aging paper: cool, but outstanding questions

December 15, 2016 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 6 Comments

A new Cell paper from Juan Carlos Izpisua Berlmonte’s group has made headlines about anti-aging across the globe because it suggests that the four core induced pluripotent stem cell (IPSC) factors use by Shinya Yamanaka to make IPSC can reverse aging. I’ve pasted the graphical abstract from the paper below and done a quick journal club style …

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Knoepfler Lab 2015: Our mission and research

September 15, 2015 February 1, 2021 / By Professor Paul Knoepfler, Ph.D.

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Many of this blog’s readers ask about my own lab’s research: what is the focus of the work in the Knoepfler Lab? You can go check out our lab website, but I thought it might be time again to blog about what we are all about as a lab and what we have been up …

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Knoepfler Lab: Our mission and research

July 29, 2014 February 1, 2021 / By Professor Paul Knoepfler, Ph.D.

Many of this The Niche‘s readers ask about what my own lab’s research. What is the focus of the research of the Knoepfler Lab? You can go check out our lab website, but I thought it might be time to blog about what we are all about as a lab and what we have been …

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New iPS cell method: drop Myc or not yet?

June 8, 2011 February 1, 2021 / By Professor Paul Knoepfler, Ph.D. / 4 Comments

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Yamanaka may have found a way to give exogenous Myc the boot from the iPS cell universe. It has always been a frustration in the iPS cell field that Myc, a proto-oncogene, is so important for reprogramming. Yes, you can make iPS cells (especially mouse) without Myc, but it can be orders of magnitude harder, …

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Tumorigenicity and Pluripotency teased apart? Not yet for Myc

August 2, 2010 February 1, 2021 / By Professor Paul Knoepfler, Ph.D.

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A paper just came out in PNAS entitled “Promotion of direct reprogramming by transformation-deficient Myc“. The main thrust of this paper is that the tumorigenic and pluripotency-related functions of Myc could be separated. It focused primarily on the lesser studied LMyc. The topic of the intertwined good (pluripotency) and bad (tumorigenicity) functions of Myc, addressed …

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