September 24, 2020

The Niche

Knoepfler lab stem cell blog

Najm

3 min read

Back-to-back papers (here and here) in Nature Biotechnology report the transdifferentiation (now often simply referred to as “direct reprogramming”) of plain old fibroblasts into brain cells called oligodendrocyte progenitor cells (OPCs). OPCs are a remarkably useful kind of brain cell that generates myelin, which insulates nerves. OPCs are thought to have great therapeutic potential for a number of pathological conditions including Multiple Sclerosis (MS) and spinal cord injury (SCI). The two teams included one from Case Western Reserve University School of Medicine led by Paul …Read More