August 10, 2020

The Niche

Knoepfler lab stem cell blog

nuclear transfer

7 min read

It’s a particularly exciting time for the stem cell field. One of the most notable developments in the last year or so is the production and preliminary study of a totally new type of human embryonic stem cells (ESC) made by nuclear transfer instead of using leftover in vitro fertilization (IVF) embryos. This process of so-called therapeutic cloning has the power to produce patient specific ESCs called NT-ESCs that can in principle be used in the future for autologous transplants for a number of diseases …Read More

4 min read

Advances in therapeutic cloning reported in the past year have been very exciting. Somatic cell nuclear transfer (SCNT) can be used to produce very powerful human embryonic stem cells (ESC). These new cells are called NT-ESCs for short. Neither embryos nor reprogramming factors are needed to produce human NT-ESCs. See here, here and here for discussions of the pioneering papers reporting creation of NT-ESC including the first paper by the lab of Shoukhrat Mitalipov of OHSU, which I called the stem cell event of the year for 2013. Now that human NT-ESC are …Read More

2 min read

A paper just came out in Nature yesterday entitled: “Nuclear genome transfer in human oocytes eliminates mitochondrial DNA variants.” It’s surely risky of me to say this, but is this paper really a clinically-relevant breakthrough for mitochondrial disease worthy of a Nature paper? The study as science is fine and very interesting, but it seems  quite questionable to me to so strongly invoke clinical relevance as they do (even if they say some stuff must be discussed first): Before proceeding with human clinical trials on …Read More