May 31, 2020

The Niche

Knoepfler lab stem cell blog

Organoids

6 min read

Last year around this time I took my annual plunge to make 20 predictions for the coming year for the stem cell and regenerative medicine field. I even made a crystal ball graphic to highlight the complexity of the stem cell ecosystem into which these predictions were embedded (see image) for 2019. How’d I do? Below I grade my 20 predictions for this year. You can in addition see my grading of my 2018 predictions here. In the next week or so I’ll also …Read More

3 min read

There’s a new paper in Cell Stem Cell on esophageal organoids that has really caught people’s attention. It is entitled, “3D Modeling of Esophageal Development using Human PSC-Derived Basal Progenitors Reveals a Critical Role for Notch Signaling.” It comes from a team led by Jianwen Que. Update: I didn’t realize when I first did this post that there were 2 related esophageal organoids papers in the same issue of the journal and the second one led by James M. Wells at Cincinnati Children’s has some cool …Read More

2 min read

I can see many reasons to be jolly on the regenerative medicine front as we get deeper into the holiday season as there is quite a lot of stem cell good news even if there is also some not so good news. In today’s post the focus is on the good news of late. Semma Therapeutics, a stem cell diabetes biotech, raised more than $110 million. I’m eager to see how the next few years play out with the healthy competition between them, ViaCyte, & …Read More

4 min read

Nominations have closed for the 2017 Stem Cell Person of the Year Award and we have a great group of nominees. I’ve listed them below in alphabetical order, along with a bit of description of who they are, which includes in some cases the language used by the nominator(s). Where possible I’ve included a link to a helpful webpage about them. You can read more about this award here in an archive of posts about it over the years. Note that folks at stem cell clinics …Read More

2 min read

Here are some stem cell weekend reads for your enjoyment along with various links and headlines. Some science pubs that caught my eye: Human Neural Stem Cell Biodistribution and Predicted Tumor Coverage by a Diffusible Therapeutic in a Mouse Glioma Model High-Content Screening in hPSC-Neural Progenitors Identifies Drug Candidates that Inhibit Zika Virus Infection in Fetal-like Organoids and Adult Brain Identification for Differential Localization of Putative Corneal Epithelial Stem Cells in Mouse and Human Tracing the origins of relapse in acute myeloid leukaemia to …Read More

4 min read

Each year around this time I check up on my past year’s predictions for the stem cell field. For 2015 I made 20 predictions. You can see past top 10 predictions lists for 2013 and 2014. It’s pretty interesting to look back at where the focus was in past years and what my crystal ball yielded for better or worse. How did I do for 2015? Below is my scoring of the 20 predictions and it’s a mixed bag. I always tend to err …Read More