October 29, 2020

The Niche

Knoepfler lab stem cell blog

Organoids

2 min read

It’s usually a tossup as to whether my weekly reads skew more towards stem cells/regenerative medicine or cancer. Other times they are more enriched for genomics and epigenetics articles. Seeds of cancer in normal skin, Nature News & Views Engineering synthetic morphogen systems that can program multicellular patterning, Science. Pig fat can be used to grow jawbones for humans, Science Mag news piece. Pig fat stem cells can aid in jawbone growth. Here’s the original Science Translational Medicine research pub. Inherited myeloproliferative neoplasm risk …Read More

3 min read

As a researcher, is there ever enough time to get to everything that you want to read especially in newer areas like stem cells, organoids, and CRISPR, without even including non-scientific reads like Shakespeare or a new novel or something like that? Hopefully, putting together lists of recommended reads like today’s post is helpful. I wonder what Shakespeare would have thought about organoids? Media including COVID-19 updates Interesting change at Nature, which will be diving more into political coverage. Here’s their editorial on this …Read More

3 min read

Clinical trials using organoids are still rare and a Clinicaltrials.gov search for such organoid work largely brings up in vitro studies. A new clinical study in Japan where organoid material will actually be transplanted into patients is causing a lot of excitement. Masayo Takahashi (高橋 政代) is a pioneer in stem cell-based clinical trial work and more specifically induced pluripotent stem cell (IPSC)-based trials. Her new clinical study is another groundbreaking step in that it is organoid based, in this case for Retinitis pigmentosa. …Read More

3 min read

Organoids are providing a novel avenue into the pathogenesis of COVID-19 and novel models for drug screening. A number of new preprints on respiratory organoids shed new light in this area. They were highlighted in a Nature newsy piece, Mini organs reveal how the coronavirus ravages the body. It’s a challenge to study COVID-19 infections because just infecting 2D cultures of various respiratory cells in a dish doesn’t necessarily tell you all you need to know about what goes on in the patient. While 3D organoids aren’t …Read More