January 17, 2021

The Niche

Trusted stem cell blog & resources

Progeria

4 min read

The paper of the week reports using base-editing, a kind of gene-editing, to reverse mutations associated with rapid aging syndromes, generally called progeria, but there are a lot of other interesting pubs to recommend for reading this week. I go over it all in this post. Gene-editing to fight premature aging syndromes In vivo base editing rescues Hutchinson–Gilford progeria syndrome in mice, Nature. This work comes from a team led by David Liu. It rightly made a big splash in the media. While it’s …Read More

4 min read

A new Cell paper from Juan Carlos Izpisua Berlmonte’s group has made headlines about anti-aging across the globe because it suggests that the four core induced pluripotent stem cell (IPSC) factors use by Shinya Yamanaka to make IPSC can reverse aging. I’ve pasted the graphical abstract from the paper below and done a quick journal club style overview based on a quick skim of the paper. Some of the media headlines are rather dramatic on this story. For instance, in a story on it over at STAT …Read More