Progeria

Weekly reads & paper of the week: gene-editing vs. aging

koblan et al 2020 nature gene editing progeria

The paper of the week reports using base-editing, a kind of gene-editing, to reverse mutations associated with rapid aging syndromes, generally called progeria, but there are a lot of other interesting pubs to recommend for reading this week. I go over it all in this post. Gene-editing to fight premature aging syndromes In vivo base …

Weekly reads & paper of the week: gene-editing vs. aging Read More »

Quick journal club on IPSC anti-aging paper: cool, but outstanding questions

IPSC-anti-aging-paper

A new Cell paper from Juan Carlos Izpisua Berlmonte’s group has made headlines about anti-aging across the globe because it suggests that the four core induced pluripotent stem cell (IPSC) factors use by Shinya Yamanaka to make IPSC can reverse aging. I’ve pasted the graphical abstract from the paper below and done a quick journal club style …

Quick journal club on IPSC anti-aging paper: cool, but outstanding questions Read More »