January 16, 2021

The Niche

Trusted stem cell blog & resources

PubPeer

4 min read

The fast-moving stem cell field has enjoyed remarkable progress in the past 10 years despite some issues such as instances of stem cell paper retraction. This “modern” stem cell era that includes induced pluripotent stem cells (IPSC) has been striking for progress despite some challenges such as issues with publications. As a maturing field it is important to view our future through the realistic lens of our past and present, which means discussing both the good and the unpleasant issues. We also have to keep things …Read More

3 min read

For the past few years post-publication peer review (PPPR) has grown in influence and one particular website, PubPeer, has become the primary go-to place specifically for blunt PPPR. The kind that happens in journal clubs in labs across the world. Comments on PubPeer have led to numerous serious corrections and retractions of flawed articles. I’m most familiar with its role in the STAP cell case. Both the founders of and most of the commenters on PubPeer have remained anonymous. That is until today. The founders …Read More

4 min read

Each year towards the end of December I make predictions for the coming year as I did for 2015. In the past I usually make a top 10 prediction list, but for this year I made 20 predictions. Admittedly some of them may have been more hopes than predictions. At mid-year today on June 30th, how am I doing with 2015 predictions? See below. Note that of course for some the jury is still out. BTW, stay tuned for more on an upcoming update …Read More

1 min read

Here are some papers and news for weekend reads. What are you reading this weekend? What are your go-to stem cell journals? Hostile Takeover: Glioma Stem Cells Recruit TAMs to Support Tumor Progression by Yu Shi, Yi-fang Ping, Xia Zhang, Xiu-wu Bian in Cell Stem Cell. YAP1 Regulates OCT4 Activity and SOX2 Expression to Facilitate self-renewal and Vascular Mimicry of Stem-like Cells by Namrata Bora-Singhal, Jonathan Nguyen, Courtney Schaal, Deepak Perumal, Sandeep Singh, Domenico Coppola, Srikumar Chellappan in Stem Cells Jacob Hannah’s team posts on bioRxiv in support …Read More

4 min read

What’s the deal with the tension between José Silva and Jacob Hanna over pluripotency? Researchers probing how to reprogram cells into powerful stem cells (induced pluripotent stem cells or IPSCs) and what the molecular mechanisms are behind this process have become entangled in a conflict. Of course over the years scientists including stem cell scientists have had their share of disagreements and debates in the past including heated ones, but this reprogramming clash has taken it up a notch beyond past ones and has some unique elements …Read More

3 min read

A heated series of discussions on stem cell publications is ongoing on the Post-publication review (post-pub) website, PubPeer, which has been called by a PubPeer user “The stem cell shoot out“. This “shoot out” goes well beyond the one page on PubPeer. It is notable to see that the authors of the papers that are the focus of these interactions, often prominent stem cell scientists, are now sometimes participating in the discussions by leaving comments themselves on PubPeer. For instance, Austin smith has commented on PubPeer regarding ground …Read More

1 min read

Post-publication (post-pub) peer review is one of the hottest topics in science today. Post-pub review means review of the scientific literature after papers come out. Post-pub review can take place on websites dedicated to it such as F1000 or PubPeer as well as on various blogs and even via comments on PubMed. In our first poll, please indicate your view on post-pub review. Then if you generally have a positive view of it, please indicate the main reason in the 2nd poll. Or if you generally …Read More

3 min read

Post-publication (post-pub) review is arguably one of the most innovative developments in scientific publishing in the past few years, including at the site PubPeer. An illustration of the widespread influence of post-pub review is the fact that PubMed recently started allowing readers to post comments about any paper.  Post-pub review drove the rapid debunking of the now retracted STAP papers. Post-pub review, which comes in two main forms (anonymous and non-anonymous), is a powerful phenomenon manifesting on a number of websites and blogs including the …Read More

2 min read

Is it really deja vu all over again with allegations of potential wrongdoing in a paper on human cloning? “Say it isn’t so!”, is basically the universal reaction I’m getting from people in the stem cell field. Well, sadly it seems to be so folks. What’s going on? Allegations have emerged on a website called PubPeer (a post-publication review kind of website) about the recent Cell paper by the Mitalipov lab on human therapeutic cloning. A person called “Peer 1” has pointed out alleged …Read More